Scientists Successfully Expand the Genetic Alphabet

This article is from the archive of our partner .

Scientists have for the first time been able to build a organism containing a new, synthetic pair of DNA units, marking a breakthrough[1] in the field of synthetic biology that has major implications for medicine.

Via Synthorx. 

In case your high school biology knowledge is a bit rusty: DNA and RNA are composed of four naturally occurring nitrogenous bases, Adenine, Thymine, Guanine and Cytosine, which pair up respectively (A-T and G-C) to make base pairs that code genetic sequences. Today’s breakthrough comes in the form of a new, synthetic pair (X-Y), which was added to the mix with successful results. The research, led by Denis Malyshev and Floyd Romesberg, is detailed in a paper titled “A semi-synthetic organism with an expanded genetic alphabet[2],” published in Nature today. The New York Times explains[3]

[The researchers] inserted an X-Y pair into the common bacterium E. coli. The bacteria were able to reproduce normally, replicating the X and Y along with the natural nucleotides. In effect, the bacteria have a genetic code of six letters rather than four, perhaps allowing them to make novel proteins. “If you have a language that has a certain number of letters, you want to add letters so you can write more words and tell more stories,” said Floyd E. Romesberg, a chemist at Scripps who led the work.

The scientists spliced the new base-pair into E. coli and saw the bacteria successfully replicate the X-Y pair when it reproduced. According to[4] fellow synthetic biologist Steven Benner, “this is the first time that you have had a living cell manage an alien genetic alphabet.” 

The researchers have already launched a company intended to monetize the discovery by using it to develop new drugs, diagnostics and vaccines, among other things. In a press release for the firm[5], Synthorx Inc., Dr. Romesberg explained that “the ability to incorporate and replicate a synthetic DNA base pair in vivo means that we have, for the first time, expanded the genetic alphabet to increase the amount of information that can be stored in DNA.” The new company’s president, Court Turner, said that[6]:

Adding X and Y to the genetic alphabet, we now have an expanded vocabulary to generate a variety of new inputs and materials for drug discovery, improved vaccines and improvements to nanotechnologies, such as microprocessing. 

The non-business synthetic biology community is also excited by the discovery. Benner told Bradley Fikes of U-T San Diego[7] that the discovery could make it easier for others in the field to be taken seriously, saying “What you think is impossible or possible depends on how you were trained. It’s a cultural statement.” 


  1. ^ marking a breakthrough (
  2. ^ A semi-synthetic organism with an expanded genetic alphabet (
  3. ^ New York Times explains (
  4. ^ According to (
  5. ^ press release for the firm (
  6. ^ said that (
  7. ^ Bradley Fikes of U-T San Diego (

Source URL: Read More
The public content above was dynamically discovered – by graded relevancy to this site’s keyword domain name. Such discovery was by systematic attempts to filter for “Creative Commons“ re-use licensing and/or by Press Release distributions. “Source URL” states the content’s owner and/or publisher. When possible, this site references the content above to generate its value-add, the dynamic sentimental analysis below, which allows us to research global sentiments across a multitude of topics related to this site’s specific keyword domain name. Additionally, when possible, this site references the content above to provide on-demand (multilingual) translations and/or to power its “Read Article to Me” feature, which reads the content aloud to visitors. Where applicable, this site also auto-generates a “References” section, which appends the content above by listing all mentioned links. Views expressed in the content above are solely those of the author(s). We do not endorse, offer to sell, promote, recommend, or, otherwise, make any statement about the content above. We reference the content above for your “reading” entertainment purposes only. Review “DMCA & Terms”, at the bottom of this site, for terms of your access and use as well as for applicable DMCA take-down request.

Acquire this Domain
You can acquire this site’s domain name! We have nurtured its online marketing value by systematically curating this site by the domain’s relevant keywords. Explore our content network – you can advertise on each or rent vs. buy the domain. | Skype: TLDtraders | +1 (475) BUY-NAME (289 – 6263). Thousands search by this site’s exact keyword domain name! Most are sent here because search engines often love the keyword. This domain can be your 24/7 lead generator! If you own it, you could capture a large amount of online traffic for your niche. Stop wasting money on ads. Instead, buy this domain to gain a long-term marketing asset. If you can’t afford to buy then you can rent the domain.

About Us
We are Internet Investors, Developers, and Franchisers – operating a content network of several thousand sites while federating 100+ eCommerce and SaaS startups. With our proprietary “inverted incubation” model, we leverage a portfolio of $100M in valued domains to impact online trends, traffic, and transactions. We use robotic process automation, machine learning, and other proprietary approaches to power our content network. Contact us to learn how we can help you with your online marketing and/or site maintenance.